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Memory master and anesthesia7/20/2023 ![]() ![]() The Morris Water Maze (MWM) was used to measure reference memory after anesthesia and surgery. Aged C57BL/6J mice were used to establish POCD models with exploratory laparotomy under isoflurane anesthesia. This study aimed to explore whether rapamycin can ameliorate anesthesia/surgery-induced cognitive deficits by inhibiting mTOR, activating autophagy and rising synaptic plasticity-related proteins in the hippocampus. The mammalian target of rapamycin (mTOR) negatively regulates the process of autophagy. ![]() In central nervous system, autophagy is vital to synaptic plasticity, homeostasis of synapticproteins, synapse elimination, spine pruning, proper axon guidance, and when dysregulated, is associated with behavioral and memory functions disorders. Previous studies demonstrated that synaptic plasticity is closely related to cognitive function, anesthesia and surgery inhibit synaptic function. Postoperative cognitive dysfunction increases mortality and morbidity in perioperative patients and has become a major concern for patients and caregivers. 3Department of Nursing, The Second Hospital of Jiaxing, The Second Affiliated Hospital of Jiaxing University, Jiaxing City, China.2Department of Anesthesiology, The Second Hospital of Jiaxing, The Second Affiliated Hospital of Jiaxing University, Jiaxing City, China. ![]() 1Department of Anesthesiology, Zhejiang Chinese Medical University, Hangzhou City, China.Sunan Gao 1†, Siyu Zhang 1†, Hongmei Zhou 2†, Xiaoyan Tao 3, Yunjian Ni 2, Daqing Pei 2, Shuai Kang 2, Weiwei Yan 2 and Jian Lu 2* ![]()
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